Endocrine Abstracts

Central diabetes insipidus is characterized by increased water excretion which is corrected by the administration of antidiuretic hormone. Hypercalciuria is known to be associated with osteoporosis. The aim was to describe the case of a patient with central diabetes insipidus, hypercalciuria, vitamin D deficiency and severe osteoporosis.The case of a patient, female aged 64 years, presenting with central diabetes insipidus, hypercalciuria, vitamin D defi...

Background and aims: DM2 has been associated with altered levels of trace elements and a prothrombotic state. We investigated the effect of a 28-day Greek mediterranean diet (rich in fiber, mono- and polyunsaturated fatty acids and complex carbohydrates) on serum concentration of trace ele-ments and blood factors participating in coagulation and fibrinolysis in 58 patients with DM2.Materials and methods: Blood trace elements and blood coagulation fac-tor...

Introduction: Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. In particular, metabolic comorbidities exert a major impact on patients’ morbidity and mortality. Diabetes mellitus, dyslipidemia and osteoporosis are among the most commonly reported metabolic comorbidities in patients with chronic lung disease. COPD patients with comorbidities, such as metabolic disease, are generally more dyspnoeic and have worse hea...

Introduction: Asthma is often associated with various comorbidities, which may affect its clinical intensity and severity. The mechanisms of adult–onset asthma may include several metabolic and inflammatory components that are common to the other diseases such as obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular diseases and psychiatric diseases.Objectives: Assessment of asthma symptom control and QoL in a subgroup of ast...

Aims: The Observational Study of Severe Osteoporosis (OSSO) is a 12-month, European, prospective study aiming to assess the changes in Health Related Quality of Life (HRQoL) of women with osteoporosis (OP) and an inadequate clinical response to antiresorptive (AR) medications.Methods: In Greece, 263 of 271 (97%) patients (pts) with severe OP met the inclusion criteria. The study population was assigned to1of 2 groups according to one or more of the follo...

Introduction: Primary hyperparathyroidism is nowadays frequently diagnosed due to routine blood calcium measured in the general biochemical profile. Primary hyperparathyroidism may be due to a parathyroid adenoma or parathyroid hyperplasia. Parathyroid adenoma may occur in the area of the parathyroid glands or may be ectopic.Aim: The aim was to describe the differential clinical expression of primary hyperparathyroidism due to an adenoma or hyperplasia i...

Adrenal adenomas are nowadays frequently diagnosed in the context of abdominal imaging. Osteoporosis may be a presenting manifestation of a cortisol producing adrenal adenoma. The aim was to present two cases of patients diagnosed and treated for osteoporosis who later in the course of the disease were diagnosed with a cortisol producing adrenal adenoma. Two patients, female aged 53 and 56 years, respectively, presented with osteoporosis. T score was −2.8 and &#...

Aim: Several studies suggest a link between vitamin D and obesity. Vitamin D may play a role in obesity. Ghrelin is an orexigenic peptide which induces obesity by central and peripheral mechanisms. Administration of ghrelin promotes food intake and decreased fat utilisation in rodents. Ghrelin levels are decreased in obese individuals.The aim of this study was to evaluate the relationship between vitamin D status and ghrelin levels.Methods: All subjects ...

Objective: Hyperprolactinemia has been reported to be associated with abnormalities of glucose metabolism and cardiovascular inflammatory markers. However, the metabolic effects of high prolactin levels are not adequately clarified. The aims of this study were to evaluate the effects of hyperprolactinemia on endothelial function, insulin sensitivity and inflammatory markers in prolactinoma diagnosed subjects.Methods: In total, 58 hyperprolactinemic subje...

Objective: Nesfatin-1, was recently discovered in the brain which is derived from nucleobindin2 (NUCB2). Central and peripheral administration of nesfatin-1, inhibits food intake, dose-dependently. Hyperthyroid patients have increased appetite and food intake with a craving for carbohydrate-rich food, at the beginning of disease, but the physiological mechanisms underlying this behavior is not known exactly. In this study, we investigated whether nesfatin-1 is involved in the ...